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Impaired stimulation of intestinal glucose absorption by portal insulin via hepatoenteral nerves in chronically ethanol‐intoxicated rats
Author(s) -
Kucera Tomas,
Jungermann Kurt,
Stümpel Frank
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01608-2
Subject(s) - stimulation , endocrinology , medicine , insulin , ethanol , absorption (acoustics) , chemistry , biochemistry , materials science , composite material
In the isolated, jointly perfused small intestine and liver of rats insulin, infused into the portal vein, induced an increase in intestinal glucose absorption via hepatoenteral cholinergic nerves. The possible loss of function of these nerves due to ethanol‐induced neuropathy was investigated with 6 weeks ethanol‐fed rats. Portal insulin or arterial carbachol failed to increase intestinal glucose absorption but cAMP still did so. The intact stimulatory effect of cAMP indicated an undisturbed capacity of the enterocytes. The loss of action of portal insulin and of arterial carbachol can be explained by the impairment of the hepatoenteral nerves in line with an ethanol‐induced neuropathy.