Premium
The first peak of the UVB irradiation‐dependent biphasic induction of vascular endothelial growth factor (VEGF) is due to phosphorylation of the epidermal growth factor receptor and independent of autocrine transforming growth factor α
Author(s) -
Blaudschun Ralf,
Brenneisen Peter,
Wlaschek Meinhard,
Meewes Christian,
Scharffetter-Kochanek Karin
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01605-7
Subject(s) - hacat , autocrine signalling , vascular endothelial growth factor , phosphorylation , tgf alpha , epidermal growth factor receptor , cancer research , growth factor , transforming growth factor , epidermal growth factor , growth factor receptor inhibitor , vascular endothelial growth factor a , angiogenesis , microbiology and biotechnology , biology , chemistry , endocrinology , cell culture , receptor , vegf receptors , biochemistry , genetics
Ultraviolet B (UVB) irradiation, the major damaging component of sunlight, has earlier been reported to enhance cutaneous angiogenesis in chronically sun‐exposed skin. We herein provide first evidence for a biphasic induction of the vascular endothelial growth factor (VEGF) following UVB irradiation of the human epidermal cell line HaCaT. The first VEGF peak occurred on mRNA level at 1 h and on protein level at 4 h postirradiation and is fully mediated by the UVB‐dependent phosphorylation of the epidermal growth factor receptor, which subsequent to its phosphorylation also initiates at least in part the synthesis of transforming growth factor α that confers as shown previously the second late VEGF peak at 8 h on mRNA and at 24 h on protein level.