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Dominant negative myostatin produces hypertrophy without hyperplasia in muscle
Author(s) -
Zhu Xiaolei,
Hadhazy Michele,
Wehling Michelle,
Tidball James G.,
McNally Elizabeth M.
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01570-2
Subject(s) - myostatin , muscle hypertrophy , medicine , myocyte , endocrinology , myokine , biology , downregulation and upregulation , hyperplasia , muscular dystrophy , negative regulator , skeletal muscle , microbiology and biotechnology , signal transduction , genetics , gene
Myostatin, a TGF‐β family member, is a negative regulator of muscle growth. Here, we generated transgenic mice that expressed myostatin mutated at its cleavage site under the control of a muscle specific promoter creating a dominant negative myostatin. These mice exhibited a significant (20–35%) increase in muscle mass that resulted from myofiber hypertrophy and not from myofiber hyperplasia. We also evaluated the role of myostatin in muscle degenerative states, such as muscular dystrophy, and found significant downregulation of myostatin. Thus, further inhibition of myostatin may permit increased muscle growth in muscle degenerative disorders.