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Ribonucleotide reductase is regulated via the R2 subunit during the life cycle of Trypanosoma brucei
Author(s) -
Breidbach Tanja,
Krauth-Siegel R.Luise,
Steverding Dietmar
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01533-7
Subject(s) - ribonucleotide reductase , trypanosoma brucei , protein subunit , biology , cell cycle , biochemistry , ribonucleotide , reductase , trypanosoma , microbiology and biotechnology , enzyme , cell , gene , genetics , nucleotide
We have examined the occurrence of the R1 and R2 subunits of ribonucleotide reductase during the life cycle of Trypanosoma brucei . Whereas the R1 protein is present throughout the life cycle, the R2 protein is not found in cell cycle‐arrested short stumpy trypanosomes. RT‐PCR/hybridization analysis revealed almost equal amounts of the R1 and R2 mRNAs in all life cycle stages of the parasite. The data indicate that ribonucleotide reductase of African trypanosomes is developmentally controlled by post‐transcriptional regulation of the R2 subunit.