Premium
Genomic structure and promoter analysis of putative mouse acetyl‐CoA transporter gene
Author(s) -
Bora Roop Singh,
Ichikawa Shinichi,
Kanamori Akiko,
Hirabayashi Yoshio
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01524-6
Subject(s) - ap 1 transcription factor , gene , tata box , biology , promoter , intron , exon , transcription factor , start codon , microbiology and biotechnology , transcription (linguistics) , genetics , gata2 , gene expression , messenger rna , linguistics , philosophy
The acetyl‐CoA transporter gene ( Acatn ) encodes a hydrophobic, multitransmembrane protein that is involved in the process of O ‐acetylation of sialic acid residues on gangliosides. O ‐Acetylated gangliosides have been found to play important roles in tissue development and organization during early embryonic stages. We have cloned the gene for mouse acetyl‐CoA transporter. The gene spans approximately 20 kb and is composed of seven exons and six introns. A single transcription initiation site, 371 bp upstream of the ATG start codon, was identified. The promoter region was found to lack a TATA box. However, several potential transcription factor binding motifs such as AP1, AP2, C/EBPα, C/EBPβ, HSF, GATA2 and MZF1 were identified in the promoter region.