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Flavonoids can replace α‐tocopherol as an antioxidant
Author(s) -
van Acker Frédérique A.A.,
Schouten Olga,
Haenen Guido R.M.M.,
van der Vijgh Wim J.F.,
Bast Aalt
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01517-9
Subject(s) - antioxidant , microsome , tocopherol , lipid peroxidation , chemistry , glutathione , biochemistry , glutathione reductase , vitamin e , gpx4 , oxidative phosphorylation , fisetin , glutathione peroxidase , enzyme , flavonoid , catalase
Endogenous antioxidants such as the lipid‐soluble vitamin E protect the cell membranes from oxidative damage. Glutathione seems to be able to regenerate α‐tocopherol via a so‐called free radical reductase. The transient protection by reduced glutathione (GSH) against lipid peroxidation in control liver microsomes is not observed in microsomes deficient in α‐tocopherol. Introduction of antioxidant flavonoids, such as 7‐monohydroxyethylrutoside, fisetin or naringenin, into the deficient microsomes restored the GSH‐dependent protection, suggesting that flavonoids can take over the role of α‐tocopherol as a chain‐breaking antioxidant in liver microsomal membranes.