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Antioxidant α‐tocopherol ameliorates glycemic control of GK rats, a model of type 2 diabetes
Author(s) -
Ihara Yu,
Yamada Yuichiro,
Toyokuni Shinya,
Miyawaki Kazumasa,
Ban Nobuhiro,
Adachi Tetsuya,
Kuroe Akira,
Iwakura Toshio,
Kubota Akira,
Hiai Hiroshi,
Seino Yutaka
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01489-7
Subject(s) - glycemic , medicine , endocrinology , glycated hemoglobin , antioxidant , type 2 diabetes , vitamin e , diabetes mellitus , oxidative stress , insulin , type 2 diabetes mellitus , chemistry , biochemistry
We have shown recently that oxidative stress by chronic hyperglycemia damages the pancreatic β‐cells of GK rats, a model of non‐obese type 2 diabetes, which may worsen diabetic condition and suggested the administration of antioxidants as a supportive therapy. To determine if natural antioxidant α‐tocopherol (vitamin E) has beneficial effects on the glycemic control of type 2 diabetes, GK rats were fed a diet containing 0, 20 or 500 mg/kg diet α‐tocopherol. Intraperitoneal glucose tolerance test revealed a significant increment of insulin secretion at 30 min and a significant decrement of blood glucose levels at 30 and 120 min after glucose loading in the GK rats fed with high α‐tocopherol diet. The levels of glycated hemoglobin A1c, an indicator of glycemic control, were also reduced. Vitamin E supplementation clearly ameliorated diabetic control of GK rats, suggesting the importance of not only dietary supplementation of natural antioxidants but also other antioxidative intervention as a supportive therapy of type 2 diabetic patients.