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The PWWP domain: a potential protein–protein interaction domain in nuclear proteins influencing differentiation?
Author(s) -
Stec Ingrid,
Nagl Sylvia B.,
van Ommen Gert-Jan B.,
den Dunnen Johan T.
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01449-6
Subject(s) - nuclear protein , biology , protein domain , amino acid , genetics , domain (mathematical analysis) , gene , protein–protein interaction , nuclear localization sequence , microbiology and biotechnology , transcription factor , mathematical analysis , mathematics
Upon characterization of WHSC1 , a gene mapping to the Wolf–Hirschhorn syndrome critical region and at its C‐terminus similar to the Drosophila ASH1/trithorax group proteins, we identified a novel protein domain designated PWWP domain. To gain insight into its structure, evolutionary conservation and its potential functional role, we performed database searches to identify other PWWP domain‐containing proteins. We retrieved 39 proteins, and a multiple alignment shows that the domain spans some 70 amino acids. It is present in proteins of nuclear origin and plays a role in cell growth and differentiation. Due to its position, the composition of amino acids close to the PWWP motif and the pattern of other domains present, we hypothesize that the domain is involved in protein–protein interactions.