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A central role for the endothelial NADPH oxidase in atherosclerosis
Author(s) -
Meyer Jamie W.,
Schmitt Mark E.
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01397-1
Subject(s) - nadph oxidase , oxidase test , chemistry , low density lipoprotein , microbiology and biotechnology , enzyme , biochemistry , biology , cholesterol
An increasing body of evidence has demonstrated that NADPH oxidase plays a critical role in several early steps leading toward the development of atherosclerosis. These effects appear to be carried out by both the ability of O 2 − to act as a small second messenger molecule, and potentially the oxidation of low density lipoprotein by O 2 − . We describe a model for the initiation and development of atherosclerosis that suggests targeted inhibition of NADPH oxidase as a powerful site for prevention and treatment of this disease.