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Distinct versus redundant properties among members of the INK4 family of cyclin‐dependent kinase inhibitors
Author(s) -
Thullberg Minna,
Bartkova Jirina,
Khan Selina,
Hansen Klaus,
Rönnstrand Lars,
Lukas Jiri,
Strauss Michael,
Bartek Jiri
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01307-7
Subject(s) - cyclin dependent kinase 6 , biology , cyclin dependent kinase , cyclin dependent kinase 4 , cell cycle , kinase , microbiology and biotechnology , carcinogenesis , genetics , cyclin dependent kinase 2 , cancer research , cell , gene
p16 INK4a , p15 INK4b , p18 INK4c and p19 INK4d comprise a family of cyclin‐dependent kinase inhibitors and tumor suppressors. We report that the INK4 proteins share the ability to arrest cells in G1, and interact with CDK4 or CDK6 with similar avidity. In contrast, only p18 and particularly p19 are phosphorylated in vivo, and each of the human INK4 proteins shows unique expression patterns dependent on cell and tissue type, and differentiation stage. Thus, the INK4 proteins harbor redundant as well as non‐overlapping properties, suggesting distinct regulatory modes, and diverse roles for the individual INK4 family members in cell cycle control, cellular differentiation, and multistep oncogenesis.