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A family of γ‐like calcium channel subunits
Author(s) -
Klugbauer Norbert,
Dai Shuiping,
Specht Verena,
Lacinová Lubica,
Marais Elsé,
Bohn Georg,
Hofmann Franz
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01306-5
Subject(s) - protein subunit , gamma subunit , calcium channel , alpha (finance) , biophysics , calcium , g alpha subunit , voltage dependent calcium channel , chemistry , biology , neuroscience , microbiology and biotechnology , biochemistry , psychology , gene , organic chemistry , clinical psychology , construct validity , psychometrics
The γ subunit was initially identified as an auxiliary subunit of the skeletal muscle calcium channel complex. Evidence for the existence of further γ subunits arose following the characterization of a genetic defect that induces epileptic seizures in stargazer mice. We present here the first account of a family of at least five putative γ subunits that are predominantly expressed in brain. The γ‐2 and γ‐4 subunits shift the steady‐state inactivation curve to more hyperpolarized potentials upon coexpression with the P/Q type α 1A subunit. The coexpression of the γ‐5 subunit accelerates the time course of current activation and inactivation of the α 1G T‐type calcium channel.