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Vascular endothelial cells synthesize and secrete brain‐derived neurotrophic factor
Author(s) -
Nakahashi Takeshi,
Fujimura Hironobu,
Altar C.Anthony,
Li Jess,
Kambayashi Jun-ichi,
Tandon Narendra N,
Sun Bing
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01302-8
Subject(s) - umbilical vein , neurotrophic factors , neurotrophin , brain derived neurotrophic factor , endocrinology , medicine , secretion , vascular endothelial growth factor b , microbiology and biotechnology , endothelial stem cell , vascular endothelial growth factor , biology , chemistry , vascular endothelial growth factor a , receptor , vegf receptors , biochemistry , in vitro
Brain‐derived neurotrophic factor (BDNF) is an abundant neurotrophin in brain and peripheral nerves, where it affects neural development, survival and repair after injury. BDNF has been detected in rat and human blood, but the source of circulating BDNF is not established. BDNF messenger and peptide were detected in cultured cells and in the culture medium of human umbilical vein endothelial cells. The expression of BDNF was up‐regulated by elevation of intracellular cAMP and down‐regulated by Ca 2+ ionophore, bovine brain extract and laminar fluid shear stress. These results suggest that vascular endothelial cells may contribute to circulating BDNF.