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Rab37 is a novel mast cell specific GTPase localized to secretory granules
Author(s) -
Masuda Esteban S.,
Luo Ying,
Young Chi,
Shen Mary,
Rossi Alex B.,
Huang Betty C.B.,
Yu Sandra,
Bennett Mark K.,
Payan Don G.,
Scheller Richard H.
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01288-6
Subject(s) - rab , microbiology and biotechnology , degranulation , gtpase , mast cell , exocytosis , golgi apparatus , biology , signal transduction , secretory pathway , effector , vesicular transport protein , vesicle , chemistry , secretion , immunology , biochemistry , receptor , membrane , endoplasmic reticulum
GTPases regulate a myriad of cellular functions including signal transduction, cytoskeletal organization and membrane trafficking. Rab GTPases act to coordinate the membrane dynamics of cells by organizing and regulating the activity of effector proteins important in vesicle trafficking. Rab37 is a novel Rab GTPase specifically expressed in the MC‐9 mast cell line and bone marrow mast cells. Rab37 is 74% identical to Rab26 and 47% identical to Rab8, a GTPase important in Golgi to plasma membrane vesicle trafficking in mammalian cells. When green fluorescent protein tagged Rab37 is expressed in bone marrow mast cells, the secretory granules are labeled. These data suggest that Rab37 may play an important role in mast cell degranulation making this protein a potentially important target for therapeutic intervention in the treatment of allergy.