Premium
Growth factor‐like effects of placental alkaline phosphatase in human fetus and mouse embryo fibroblasts
Author(s) -
She Qing-Bai,
Mukherjee Jagat J,
Huang Jin-Sheng,
Crilly Karan S,
Kiss Zoltan
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01273-4
Subject(s) - kinase , alkaline phosphatase , fetus , biology , placenta , endocrinology , protein kinase b , embryo , microbiology and biotechnology , medicine , chemistry , signal transduction , biochemistry , pregnancy , enzyme , genetics
Human placental alkaline phosphatase (PALP) is synthesized in the placenta during pregnancy and is also expressed in many cancer patients; however, its physiological role is unknown. Here we show that in human fetus fibroblasts as well as normal and H‐ras‐transformed mouse embryo fibroblasts PALP stimulates DNA synthesis and cell proliferation in synergism with insulin, zinc and calcium. The mitogenic effects of PALP are associated with the activation of c‐Raf‐1, p42/p44 mitogen‐activated protein kinases, p70 S6 kinase, Akt/PKB kinase and phosphatidylinositol 3′‐kinase. The results suggest that in vivo PALP may promote fetus development as well as the growth of cancer cells which express oncogenic Ras.