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Olive oil phenolics are dose‐dependently absorbed in humans
Author(s) -
Visioli Francesco,
Galli Claudio,
Bornet Francis,
Mattei Alissa,
Patelli Rossana,
Galli Giovanni,
Caruso Donatella
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01216-3
Subject(s) - tyrosol , hydroxytyrosol , glucuronide , olive oil , chemistry , ingestion , antioxidant , urine , absorption (acoustics) , food science , phenols , pharmacology , polyphenol , chromatography , biochemistry , biology , physics , acoustics
Olive oil phenolic constituents have been shown, in vitro, to be endowed with potent biological activities including, but not limited to, an antioxidant action. To date, there is no information on the absorption and disposition of such compounds in humans. We report that olive oil phenolics, namely tyrosol and hydroxytyrosol, are dose‐dependently absorbed in humans after ingestion and that they are excreted in the urine as glucuronide conjugates. Furthermore, an increase in the dose of phenolics administered increased the proportion of conjugation with glucuronide.