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The high molecular weight isoforms of basic fibroblast growth factor (FGF‐2): an insight into an intracrine mechanism
Author(s) -
Delrieu Isabelle
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01189-3
Subject(s) - intracrine , gene isoform , fibroblast growth factor , intracellular , microbiology and biotechnology , fibroblast growth factor receptor , cytosol , receptor , growth factor , biology , cell surface receptor , biochemistry , chemistry , autocrine signalling , gene , enzyme
Basic fibroblast growth factor (FGF‐2) is an important modulator of cell growth and differentiation under both physiological and pathological conditions. Until recently, most investigations into the FGF‐2 signalling pathway were concerned with its interaction with specific membrane receptors. Nevertheless, while a 18 kDa protein of FGF‐2 is cytosolic, there are also co‐translated high molecular weight (HMW) isoforms that are predominantly located in the cell nucleus. An increasing amount of data strongly argue in favour of distinct biological functions depending on the subcellular location of the FGF‐2 species. This review describes the evidence concerning the strictly intracellular mode of action of the HMW isoforms of FGF‐2.