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Suppression of GD1α ganglioside‐mediated tumor metastasis by liposomalized WHW‐peptide
Author(s) -
Takikawa Masako,
Kikkawa Hironori,
Asai Tomohiro,
Yamaguchi Naoto,
Ishikawa Dai,
Tanaka Michinori,
Ogino Koichi,
Taki Takao,
Oku Naoto
Publication year - 2000
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(00)01110-8
Subject(s) - ganglioside , peptide , metastasis , chemistry , cancer research , medicine , biochemistry , cancer
GD1α ganglioside‐replica peptides were recently isolated from a phage‐displayed random pentadecapeptide library by assaying for inhibition of adhesion of RAW117‐H10 lymphosarcoma cells to hepatic sinusoidal microvessel endothelial (HSE) cells. We show here that the Trp‐His‐Trp (WHW) peptide was identified as a minimal sequence of the GD1α‐replica peptide WHWRHRIPLQLAAGR. The addition of WHW peptide‐attached liposomes displayed efficient inhibition of liver metastasis of RAW117‐H10 cells as well as of GD1α‐mediated adhesion of RAW117‐H10 cells to HSE cells in vitro. These results suggest that engineered liposomes for peptide delivery are applicable to treatment for metastasis.