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Effects of tobacco smoking and abstinence on middle latency auditory evoked potentials
Author(s) -
Kishimoto Takuzo,
Domino Edward F.
Publication year - 1998
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1016/s0009-9236(98)90108-4
Subject(s) - abstinence , audiology , medicine , arousal , latency (audio) , cigarette smoking , smoking cessation , psychology , anesthesia , physiology , psychiatry , neuroscience , electrical engineering , engineering , pathology
Objective To evaluate the effects of tobacco cigarette smoking and overnight abstinence on middle latency auditory evoked potentials among smokers and nonsmokers. Methods Groups of 9 to 10 adult male and female nonsmokers and smokers participated in the study. Each person volunteered for two laboratory sessions conducted in the early afternoon on 2 separate days. Smokers abstained from tobacco products 6 to 15 hours before the abstinent session and maintained their usual smoking behavior before the smoking session. The nonsmokers had a similar laboratory experience but sham smoked by means of inhaling air. Middle latency auditory evoked potentials were recorded from Cz to both ears as reference. Results The latencies of the Na and Pa potentials during the smoking session were significantly ( p < 0.01) shorter than those in abstinent smokers and nonsmokers. After smoking, peak‐to‐trough amplitudes for the V‐Na, Na‐Pa, and Pa‐Nb potentials were larger than those after abstinence and significantly larger than those among nonsmokers. Conclusions The shorter latencies of the middle latency brain wave components in the smoking session suggest faster processing of sensory information after cigarette smoking. Larger Pa amplitudes after cigarette smoking suggest a higher arousal level than that among partially abstinent smokers and nonsmokers. Clinical Pharmacology & Therapeutics (1998) 63 , 571–579; doi: