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Cerebrospinal fluid prostaglandins after systemic dipyrone intake
Author(s) -
Levy Micha,
Brune Kay,
ZylberKatz Ester,
Cohen Oren,
Caraco Yoseph,
Geisslinger Gerd
Publication year - 1998
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1016/s0009-9236(98)90029-7
Subject(s) - cerebrospinal fluid , medicine , pharmacology
Objective The object of this study was to evaluate the time course of thromboxane B 2 and prostaglandin E 2 concentrations in cerebrospinal fluid after oral administration of dipyrone (INN, metamizole). Methods A single 1.0 gm oral dose of dipyrone was given to consenting patients undergoing elective diagnostic lumbar puncture 0.5, 1, 1.5, 2, 4, 6, 8, or 12 hours before the tap. Results For thromboxane B 2 a time decrease in cerebrospinal fluid concentration was apparent. In contrast, for prostaglandin E 2 cerebrospinal fluid levels no consistent trend was observed. Conclusions A time‐related decrease in cerebrospinal fluid thromboxane B 2 level was noted in patients receiving dipyrone. Thirty minutes after dipyrone intake cerebrospinal fluid thromboxane B 2 levels already tended to be lower than those seen in patients with neurologic diseases who were not receiving dipyrone. These results are consistent with the hypothesis that dipyrone acts in the central nervous system by inhibition of particular prostanoids. Clinical Pharmacology & Therapeutics (1998) 64 , 117–122; doi: