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Differential effects of oral losartan and enalapril on local venous and systemic pressor responses to angiotensin I and II in healthy men
Author(s) -
Goldberg Michael R.,
Mey Christian,
Wroblewski Jill M.,
Li Qian,
Schroeter Volkmar,
Belz Gustav G.
Publication year - 1996
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1016/s0009-9236(96)90026-0
Subject(s) - losartan , medicine , enalapril , angiotensin ii , renin–angiotensin system , pharmacology , angiotensin converting enzyme , blood pressure
This double‐blind, placebo‐controlled crossover study was designed to differentiate the pharmacodynamic effects of the angiotensin II receptor antagonist losartan from the angiotensin converting enzyme inhibitor enalapril. Effects of placebo, enalapril (10 mg), and losartan (20 and 100 mg) on local venous and systemic pressor responses to angiotensin I and II were compared in eight healthy male subjects. Treatments were administered orally approximately 4 hours before agonist infusions into a dorsal hand vein. Local changes in hand vein diameter and systemic blood pressure were monitored during the infusions. The 100 mg dose of losartan attenuated local venoconstrictor and systemic pressor responses to angiotensin I and II. In contrast, enalapril blocked only responses to angiotensin I. Both losartan and enalapril increased plasma renin concentration compared with placebo. These results are consistent with direct antagonism of angiotensin II receptors by losartan and with indirect effects of enalapril through inhibition of angiotensin converting enzyme. Clinical Pharmacology & Therapeutics (1996) 59 , 72–82; doi: