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Correlation of intrinsic clearance estimates for erythromycin N‐demethylation (ERMND) and midazolam 1′‐hydroxylation (MDZOH) with CYP3A4 and CYP3A5 content using human liver microsomes (HLM)
Author(s) -
Lyke A.C.,
Nelsen A.C.,
Paine M.F.,
Rowland E.E.,
Kashuba A.D.,
Lindley C.,
Clarke M.J.,
Hawke R.L.
Publication year - 2003
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1016/s0009-9236(03)90426-7
Subject(s) - cyp3a4 , midazolam , microsome , erythromycin , cyp3a5 , demethylation , cyp3a , hydroxylation , cytochrome p450 , chemistry , pharmacology , medicine , metabolism , antibiotics , biochemistry , enzyme , genotype , gene expression , sedation , dna methylation , gene
Clinical Pharmacology & Therapeutics (2003) 73 , P19–P19; doi: