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The Role of 5‐HT 3 Receptor Antagonists in Preventing Postoperative Nausea and Vomiting
Author(s) -
Board Thomas,
Board Rhonda
Publication year - 2006
Publication title -
aorn journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.222
H-Index - 43
eISSN - 1878-0369
pISSN - 0001-2092
DOI - 10.1016/s0001-2092(06)60241-x
Subject(s) - granisetron , ondansetron , medicine , vomiting , nausea , postoperative nausea and vomiting , anesthesia , antagonist , 5 ht3 receptor , pharmacology , palonosetron , antiemetic , serotonin , 5 ht receptor , receptor
• POSTOPERATIVE NAUSEA AND VOMITING (PONV) is a frequent complication of surgery. Guidelines recommend using a 5‐HT 3 receptor antagonist (eg, ondansetron, dolasetron, granisetron) combined with a second agent (eg, dexamethasone) for patients at moderate to high risk for PONV. • ALTHOUGH ALL 5‐HT 3 ANTAGONISTS are effective, ondansetron and granisetron have been found to be effective at substantially lower doses than those approved by the US Food and Drug Administration. Metabolism of granisetron differs from metabolism of other 5‐HT 3 antagonists, so it is less likely to adversely interact with other medications. • THIS ARTICLE EXPLAINS the clinical pharmacology of 5‐HT 3 antagonists and provides recommendations for nursing management of PONV. AORN J 83 (January 2006) 209–220.