Open AccessSingle session of high-intensity focused ultrasound therapy for the management of organ-confined prostate cancer: A single-institute experience
Author(s) -
Yu-Cing Juho,
ShengTang Wu,
TaiLung Cha,
GuangHuan Sun,
DahShyong Yü,
Chung-Cheng Kao
Publication year - 2016
Publication title -
urological science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.155
H-Index - 8
eISSN - 1879-5234
pISSN - 1879-5226
DOI - 10.1016/j.urols.2016.09.002
Subject(s) - medicine , prostate cancer , high intensity focused ultrasound , prostate , prostate specific antigen , cancer , urology , ultrasound , oncology , surgery , radiology
Objective: The aim of this study was to evaluate the therapeutic response and complications of high-intensity focused ultrasound for patients with localized prostate cancer.Materials and Methods: We evaluated the clinical outcomes of 29 patients who received high-intensity focused ultrasound as first-line treatment for localized prostate cancer at our hospital from October 2010 to March 2016. Biochemical recurrence was defined, according to the Stuttgart definition of biochemical failure, as the prostate-specific antigen nadir plus 1.2 ng/mL. Prostate-specific antigen levels and complications were recorded during regular follow-up.Results: The mean follow-up period was 24.6 months. Six patients experienced biochemical recurrence (20.68%). Disease progression was noted in six patients (20.68%), and salvage therapy was performed in these patients. The 24.6-month cancer-specific survival rate was 100%. No severe complications were reported.Conclusion: High-intensity focused ultrasound is an alternative therapy for patients with localized prostate cancer. In combination with preceding transurethral resection of the prostate, this treatment shows promise in disease control with a low complication rate in short-term follow-up