Intervention in COVID-19 linked hypercoaguable states characterized by circuit thrombosis utilizing a direct thrombin inhibitor | Zendy

Madhav Seshadri | Zendy; Jasimuddin Ahamed | Zendy; Jeffrey Laurence | Zendy

Open Access

Intervention in COVID-19 linked hypercoaguable states characterized by circuit thrombosis utilizing a direct thrombin inhibitor

Author(s) -

Madhav Seshadri,

Jasimuddin Ahamed,

Jeffrey Laurence

Publication year - 2020

Publication title -

thrombosis update

Language(s) - English

Resource type - Journals

ISSN - 2666-5727

DOI - 10.1016/j.tru.2020.100009

Subject(s) - argatroban , thrombosis , direct thrombin inhibitor , heparin , fibrinogen , thrombin , discovery and development of direct thrombin inhibitors , medicine , pharmacology , cardiology , warfarin , platelet , atrial fibrillation , dabigatran

Highlights • Circuit thrombosis complicates CRRT in COVID-19 despite standard heparin-based anticoagulation regimens.• 5 cases of CRRT thrombosis despite heparin-based anticoagulation resolved using a direct thrombin inhibitor, argatroban.• Changes in fibrinogen levels better reflected response to anticoagulation than did changes in D-dimer levels.• High fibrinogen levels and decreased anti-thrombin III activity may relate to argatroban superiority in these cases.

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