Open AccessThe Sant Pau Initiative on Neurodegeneration (SPIN) cohort: A data set for biomarker discovery and validation in neurodegenerative disorders
Author(s) -
Alcolea Daniel,
Clarimón Jordi,
CarmonaIragui María,
IllánGala Ignacio,
MorenasRodríguez Estrella,
Barroeta Isabel,
RibosaNogué Roser,
Sala Isabel,
SánchezSaudinós M. Belén,
Videla Laura,
Subirana Andrea,
Benejam Bessy,
Valldeneu Sílvia,
Fernández Susana,
Estellés Teresa,
Altuna Miren,
SantosSantos Miguel,
GarcíaLosada Lídia,
Bejanin Alexandre,
Pegueroles Jordi,
Montal Víctor,
Vilaplana Eduard,
Belbin Olivia,
DolsIcardo Oriol,
Sirisi Sònia,
QuerolVilaseca Marta,
CerveraCarles Laura,
Muñoz Laia,
Núñez Raúl,
Torres Soraya,
Camacho M. Valle,
Carrió Ignasi,
Giménez Sandra,
Delaby Constance,
RojasGarcia Ricard,
TuronSans Janina,
Pagonabarraga Javier,
Jiménez Amanda,
Blesa Rafael,
Fortea Juan,
Lleó Alberto
Publication year - 2019
Publication title -
alzheimer's and dementia: translational research and clinical interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.49
H-Index - 30
ISSN - 2352-8737
DOI - 10.1016/j.trci.2019.09.005
Subject(s) - biomarker , neurodegeneration , medicine , cohort , neuropsychology , imaging biomarker , neuroimaging , disease , cohort study , medical physics , oncology , neuroscience , pathology , psychology , magnetic resonance imaging , psychiatry , radiology , biology , cognition , biochemistry
The SPIN (Sant Pau Initiative on Neurodegeneration) cohort is a multimodal biomarker platform designed for neurodegenerative disease research following an integrative approach. Methods Participants of the SPIN cohort provide informed consent to donate blood and cerebrospinal fluid samples, receive detailed neurological and neuropsychological evaluations, and undergo a structural 3T brain MRI scan. A subset also undergoes other functional or imaging studies (video‐polysomnogram, 18 F‐fluorodeoxyglucose PET, amyloid PET, Tau PET). Participants are followed annually for a minimum of 4 years, with repeated cerebrospinal fluid collection and imaging studies performed every other year, and brain donation is encouraged. Results The integration of clinical, neuropsychological, genetic, biochemical, imaging, and neuropathological information and the harmonization of protocols under the same umbrella allows the discovery and validation of key biomarkers across several neurodegenerative diseases. Discussion We describe our particular 10‐year experience and how different research projects were unified under an umbrella biomarker program, which might be of help to other research teams pursuing similar approaches.