Open AccessLatent class analysis identifies functional decline with Amsterdam IADL in preclinical Alzheimer's disease
Author(s) -
Villeneuve SarahChristine,
Houot Marion,
Cacciamani Federica,
Verrijp Merike,
Dubois Bruno,
Sikkes Sietske,
Epelbaum Stéphane,
Bakardjian Hovagim,
Benali Habib,
Bertin Hugo,
LaurieBoukadida Joel Bonheur,
Boukerrou Nadia,
Cavedo Enrica,
Chiesa Patrizia,
Colliot Olivier,
Dubois Bruno,
Dubois Marion,
Epelbaum Stéphane,
Gagliardi Geoffroy,
Genthon Remy,
Habert MarieOdile,
Hampel Harald,
Houot Marion,
Kas Aurélie,
Lamari Foudil,
Levy Marcel,
Lista Simone,
Metzinger Christiane,
Mochel Fanny,
Nyasse Francis,
Poisson Catherine,
Potier MarieClaude,
Revillon Marie,
Santos Antonio,
Andrade Katia Santos,
Sole Marine,
Surtee Mohmed,
Thiebaud de Schotten Michel,
Vergallo Andrea,
Younsi Nadjia
Publication year - 2019
Publication title -
alzheimer's and dementia: translational research and clinical interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.49
H-Index - 30
ISSN - 2352-8737
DOI - 10.1016/j.trci.2019.08.009
Subject(s) - activities of daily living , gerontology , disease , psychology , alzheimer's disease , asymptomatic , cohort , medicine , psychiatry
Trials in Alzheimer's disease (AD) now include participants at the earliest stages to prevent further decline. However, the lack of tools sensitive to subtle functional changes in early‐stage AD hinders the development of new therapies as it is difficult to prove their clinical relevance. Methods We assessed functional changes over three years in 289 elderly memory complainers from the Investigation of Alzheimer's Predictors in subjective memory complainers cohort using the Amsterdam Instrumental‐Activities‐of‐Daily‐Living questionnaire (A‐IADL‐Q). Results No overall functional decline related to AD imaging markers was evidenced. However, five distinct classes of A‐IADL‐Q trajectories were identified. The largest class (212 [73.4%]) had stable A‐IADL‐Q scores over 3 years. A second group (23 [8.0%]) showed a persistent functional decline, higher amyloid load ( P = .0005), and lower education ( P = .0392). Discussion The A‐IADL‐Q identified a subtle functional decline in asymptomatic at‐risk AD individuals. This could have important implications in the field of early intervention in AD.