Open AccessCerebrospinal fluid neurogranin/β‐site APP‐cleaving enzyme 1 predicts cognitive decline in preclinical Alzheimer's disease
Author(s) -
Kirsebom BjørnEivind,
Nordengen Kaja,
Selnes Per,
Waterloo Knut,
Torsetnes Silje Bøen,
Gísladóttir Berglind,
Brix Britta,
Vanmechelen Eugeen,
Bråthen Geir,
Hessen Erik,
Aarsland Dag,
Fladby Tormod
Publication year - 2018
Publication title -
alzheimer's and dementia: translational research and clinical interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.49
H-Index - 30
ISSN - 2352-8737
DOI - 10.1016/j.trci.2018.10.003
Subject(s) - neurogranin , cerebrospinal fluid , cognitive decline , apolipoprotein e , medicine , psychology , cognition , hippocampus , hippocampal formation , alzheimer's disease , neuroscience , dementia , endocrinology , effects of sleep deprivation on cognitive performance , disease , chemistry , enzyme , biochemistry , protein kinase c
The cerebrospinal fluid neurogranin (Ng)/β‐site amyloid precursor protein‐cleaving enzyme 1 (BACE1) ratio may reflect synaptic affection resulting from reduced beta‐amyloid (Aβ) clearance. We hypothesize that increased Ng/BACE1 ratio predicts the earliest cognitive decline in Alzheimer's disease. Methods We compared Ng/BACE1 levels between cases with subjective cognitive decline (n = 18) and mild cognitive impairment (n = 20) both with amyloid plaques and healthy controls ( APOE ‐ε4+, n = 16; APOE ‐ε4‐, n = 20). We performed regression analyses between cerebrospinal fluid levels, baseline hippocampal and amygdala volumes, and pertinent cognitive measures (memory, attention, Mini Mental State Examination [MMSE]) at baseline and after 2 years. Results Ng/BACE1 levels were elevated in both subjective cognitive decline and mild cognitive impairment compared to healthy controls. Higher Ng/BACE1 ratio was associated with lower hippocampal and amygdala volumes; lower baseline memory functions, attention, and MMSE; and significant decline in MMSE and memory function at 2‐year follow‐up. Discussion High Ng/BACE1 ratio predicts cognitive decline also in preclinical cases with amyloid plaques.