Open AccessLifestyle and neurodegeneration in midlife as expressed on functional magnetic resonance imaging: A systematic review
Author(s) -
Topiwala Hinesh,
Terrera Graciela Muniz,
Stirland Lucy,
Saunderson Kathryn,
Russ Tom C.,
Dozier Marshall F.,
Ritchie Craig W.
Publication year - 2018
Publication title -
alzheimer's and dementia: translational research and clinical interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.49
H-Index - 30
ISSN - 2352-8737
DOI - 10.1016/j.trci.2018.04.001
Subject(s) - psycinfo , neurodegeneration , functional magnetic resonance imaging , medline , cognition , medicine , magnetic resonance imaging , psychology , gerontology , clinical psychology , physical medicine and rehabilitation , neuroscience , psychiatry , biology , disease , biochemistry , radiology
Lifestyle factors may influence brain health in midlife. Functional magnetic resonance imaging is a widely used tool to investigate early changes in brain health, including neurodegeneration. In this systematic review, we evaluate the relationship between lifestyle factors and neurodegeneration in midlife, as expressed using functional magnetic resonance imaging. Methods We searched MEDLINE, EMBASE, and PsycINFO combining subject headings and free text terms adapted for each database. Articles were screened, and their quality was assessed independently by two reviewers before final inclusion in the review. Results We screened 4116 studies and included 29 in the review. Seven lifestyle factors, such as alcohol, cognitive training, excessive internet use, fasting, physical training, smoking, and substance misuse, were identified in this review. Discussion Cognitive and physical trainings appear to be associated with a neuroprotective effect, whereas alcohol misuse, smoking, and substance misuse appear to be associated with neurodegeneration. Further research is required into the effects of excessive internet use and fasting.