Open AccessAn 8‐week, open‐label, dose‐finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations
Author(s) -
Sha Sharon J.,
Miller Zachary A.,
Min Sangwon,
Zhou Yungui,
Brown Jesse,
Mitic Laura L.,
Karydas Anna,
Koestler Mary,
Tsai Richard,
CorbettaRastelli Chiara,
Lin Sophie,
Hare Emma,
Fields Scott,
Fleischmann Kirsten E.,
Powers Ryan,
Fitch Ryan,
Martens Lauren Herl,
Shamloo Mehrdad,
Fagan Anne M.,
Farese Robert V.,
Pearlman Rodney,
Seeley William,
Miller Bruce L.,
Gan Li,
Boxer Adam L.
Publication year - 2017
Publication title -
alzheimer's and dementia: translational research and clinical interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.49
H-Index - 30
ISSN - 2352-8737
DOI - 10.1016/j.trci.2017.08.002
Subject(s) - tolerability , medicine , cerebrospinal fluid , nimodipine , atrophy , adverse effect , frontotemporal lobar degeneration , pharmacology , anesthesia , pathology , oncology , calcium , dementia , disease , frontotemporal dementia
Frontotemporal lobar degeneration–causing mutations in the progranulin ( GRN ) gene reduce progranulin protein (PGRN) levels, suggesting that restoring PGRN in mutation carriers may be therapeutic. Nimodipine, a Food and Drug Administration–approved blood‐brain barrier‐penetrant calcium channel blocker, increased PGRN levels in PGRN‐deficient murine models. We sought to assess safety and tolerability of oral nimodipine in human GRN mutation carriers. Methods We performed an open‐label, 8‐week, dose‐finding, phase 1 clinical trial in eight GRN mutation carriers to assess the safety and tolerability of nimodipine and assayed fluid and radiologic markers to investigate therapeutic endpoints. Results There were no serious adverse events; however, PGRN concentrations (cerebrospinal fluid and plasma) did not change significantly following treatment (percent changes of −5.2 ± 10.9% in plasma and −10.2 ± 7.8% in cerebrospinal fluid). Measurable atrophy within the left middle frontal gyrus was observed over an 8‐week period. Discussion While well tolerated, nimodipine treatment did not alter PGRN concentrations or secondary outcomes.