Open AccessGamma rhythm low field magnetic stimulation alleviates neuropathologic changes and rescues memory and cognitive impairments in a mouse model of Alzheimer's disease
Author(s) -
Zhen Junli,
Qian Yanjing,
Weng Xiechuan,
Su Wenting,
Zhang Jianliang,
Cai Lihui,
Dong Lin,
An Haiting,
Su Ruijun,
Wang Jiang,
Zheng Yan,
Wang Xiaomin
Publication year - 2017
Publication title -
alzheimer's and dementia: translational research and clinical interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.49
H-Index - 30
ISSN - 2352-8737
DOI - 10.1016/j.trci.2017.07.002
Subject(s) - neuroscience , hippocampal formation , long term potentiation , neurochemical , presenilin , stimulation , hippocampus , psychology , alzheimer's disease , genetically modified mouse , medicine , transgene , biology , disease , receptor , biochemistry , gene
The abnormal amyloid β (Aβ) accumulation and Aβ‐related neural network dysfunction are considered central to the pathogenesis of Alzheimer's disease (AD) at the early stage. Deep‐brain reachable low field magnetic stimulation (DMS), a novel noninvasive approach that was designed to intervene the network activity in brains, has been found to alleviate stress‐related cognitive impairments. Methods Amyloid precursor protein/presenilin‐1 transgenic mice (5XFAD) were treated with DMS, and cognitive behavior and AD‐like pathologic changes in the neurochemical and electrophysiological properties in 5XFAD mice were assessed. Results We demonstrate that DMS treatment enhances cognitive performances, attenuates Aβ load, upregulates postsynaptic density protein 95 level, and promotes hippocampal long‐term potentiation in 5XFAD mouse brain. Intriguingly, the gamma burst magnetic stimulation reverses the aberrant gamma oscillations in the transgenic hippocampal network. Discussion This work establishes a solid foundation for the effectiveness of DMS in treating AD and proposes a future study of gamma rhythm stimulation on reorganizing rhythmic neural activity in AD brain.