Open AccessNeuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms
Author(s) -
Lanctôt Krista L.,
Amatniek Joan,
AncoliIsrael Sonia,
Arnold Steven E.,
Ballard Clive,
CohenMansfield Jiska,
Ismail Zahinoor,
Lyketsos Constantine,
Miller David S.,
Musiek Erik,
Osorio Ricardo S.,
Rosenberg Paul B.,
Satlin Andrew,
Steffens David,
Tariot Pierre,
Bain Lisa J.,
Carrillo Maria C.,
Hendrix James A.,
Jurgens Heidi,
Boot Brendon
Publication year - 2017
Publication title -
alzheimer's and dementia: translational research and clinical interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.49
H-Index - 30
ISSN - 2352-8737
DOI - 10.1016/j.trci.2017.07.001
Subject(s) - apathy , dementia , neurocognitive , disease , psychiatry , depression (economics) , distress , medicine , psychology , psychosis , clinical trial , cognition , clinical psychology , economics , macroeconomics
Neuropsychiatric symptoms (NPSs) are hallmarks of Alzheimer's disease (AD), causing substantial distress for both people with dementia and their caregivers, and contributing to early institutionalization. They are among the earliest signs and symptoms of neurocognitive disorders and incipient cognitive decline, yet are under‐recognized and often challenging to treat. With this in mind, the Alzheimer's Association convened a Research Roundtable in May 2016, bringing together experts from academia, industry, and regulatory agencies to discuss the latest understanding of NPSs and review the development of therapeutics and biomarkers of NPSs in AD. This review will explore the neurobiology of NPSs in AD and specific symptoms common in AD such as psychosis, agitation, apathy, depression, and sleep disturbances. In addition, clinical trial designs for NPSs in AD and regulatory considerations will be discussed.