English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Background  Two previous studies of SB742457, a 5‐hydroxytryptamine (5‐HT 6 ) receptor antagonist, suggested the efficacy of improvements in cognition and global outcome in Alzheimer's disease (AD).    Methods  Two randomized, placebo‐controlled trials investigated SB742457 15 and 35 mg daily in subjects with mild‐to‐moderate AD (Mini‐Mental Health State Examination [MMSE] 10–26). Study 1 (n = 576) investigated SB742457 and donepezil (5–10 mg daily) as monotherapy for 6 months. Study 2 (n = 684) investigated SB742457 in subjects who were maintained on donepezil. Coprimary endpoints at 24 weeks assessed cognition (AD Assessment Scale‐Cognitive Subscale [ADAS‐Cog]) and global outcome (Study 1: Clinician Interview‐Based Impression of Change Plus Caregiver Input [CIBIC+]; Study 2: Clinical Dementia Rating‐Sum of Boxes [CDR‐SB]). Safety was assessed throughout.    Results  Both studies failed to achieve formal statistical significance for their primary objectives. Study 1: SB742457 monotherapy was not statistically significantly different from placebo on any endpoint. Donepezil improved CIBIC+ but not ADAS‐Cog. Study 2: SB742457 35 mg showed statistically significant differences relative to placebo for ADAS‐cog (weeks 12, 24, and 48, but not week 36), ADCS‐ADL (weeks 12–36, but not week 48), and CDR‐SB (week 12 only).    Conclusion  Neither study met the overall criteria for success, but as an adjunct to donepezil, SB742457 was associated with sustained improvements for up to 48 weeks in cognition and ADL, compared with donepezil alone.  Clinical Trial Registration:  Clinicaltrials.gov : Study 1  NCT00708552 ; Study 2  NCT00710684 .

Two randomized controlled trials of SB742457 in mild‐to‐moderate Alzheimer's disease