Furin cleavage sites naturally occur in coronaviruses | Zendy

Yiran Wu | Zendy; Suwen Zhao | Zendy

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Furin cleavage sites naturally occur in coronaviruses

Author(s) -

Yiran Wu,

Suwen Zhao

Publication year - 2020

Publication title -

stem cell research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.654

H-Index - 65

eISSN - 1876-7753

pISSN - 1873-5061

DOI - 10.1016/j.scr.2020.102115

Subject(s) - furin , biology , coronavirus , cleavage (geology) , phylogenetic tree , coding region , virology , covid-19 , peptide sequence , genetics , gene , biochemistry , enzyme , medicine , paleontology , disease , pathology , fracture (geology) , infectious disease (medical specialty)

The spike protein is a focused target of COVID-19, a pandemic caused by SARS-CoV-2. A 12-nt insertion at S1/S2 in the spike coding sequence yields a furin cleavage site, which raised controversy views on origin of the virus. Here we analyzed the phylogenetic relationships of coronavirus spike proteins and mapped furin recognition motif on the tree. Furin cleavage sites occurred independently for multiple times in the evolution of the coronavirus family, supporting the natural occurring hypothesis of SARS-CoV-2.

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