Derivation of induced pluripotent stem cells (SDUKIi003-A) from a 20-year-old male patient diagnosed with Asperger syndrome | Zendy

Morad Kamand | Zendy; Mirolyuba Ilieva | Zendy; Sheena Louise Forsberg | Zendy; Mads Thomassen | Zendy; Morten Meyer | Zendy; Åsa Fex Svenningsen | Zendy; Tanja Maria Michel | Zendy

Open Access

Derivation of induced pluripotent stem cells (SDUKIi003-A) from a 20-year-old male patient diagnosed with Asperger syndrome

Author(s) -

Morad Kamand,

Mirolyuba Ilieva,

Sheena Louise Forsberg,

Mads Thomassen,

Morten Meyer,

Åsa Fex Svenningsen,

Tanja Maria Michel

Publication year - 2020

Publication title -

stem cell research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.654

H-Index - 65

eISSN - 1876-7753

pISSN - 1873-5061

DOI - 10.1016/j.scr.2020.101974

Subject(s) - biology , induced pluripotent stem cell , stem cell , asperger syndrome , genetics , embryonic stem cell , medicine , bioinformatics , autism , psychiatry , gene , psychology

Autism spectrum disorder is a heterogenous neurodevelopmental disorder. The patients experience challenges in social interaction and communication skills as well as restricted and/or repetitive behaviors. To understand the molecular mechanisms underlying developmental brain disorders, patient-derived cellular models represent a useful tool. We have generated a human induced pluripotent stem cell line (SDUKIi003-A) from skin fibroblasts derived from a 20-year old male patient diagnosed with Asperger syndrome ("FYNEN-cohort" of Southern Denmark). The reprogramming of the fibroblasts was accomplished using integration-free episomal plasmids. Characterization validated the expression of pluripotency markers, differentiation into the three germ layers, and absence of chromosomal abnormalities.

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