Open AccessGreen procedure for the synthesis of bis(indolyl)methanes in water
Author(s) -
Najmedin Azizi,
E. Gholibeghlo,
Zohreh Manocheri
Publication year - 2012
Publication title -
scientia iranica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.299
H-Index - 51
eISSN - 2345-3605
pISSN - 1026-3098
DOI - 10.1016/j.scient.2011.11.043
Subject(s) - squaric acid , chemistry , indole test , electrophile , electrophilic substitution , green chemistry , catalysis , organic chemistry , environmentally friendly , combinatorial chemistry , moisture , reaction mechanism , ecology , biology
A green and environmentally benign protocol for squaric acid catalyst electrophilic substitution reactions of indole derivatives, with various aldehydes in water, in good to excellent yields, is developed. The advantages of low sensitivity towards moisture and oxygen, high tolerance of different functional groups, green reaction media and efficient recyclability make this organocatalyst suitable for both laboratory and industrial scale synthesis of bis(indolyl)methanes under very mild conditions