Open AccessFalse negative SARS-CoV-2 PCR - A case report and literature review
Author(s) -
Jessica M. Wiseman,
T.A. D'Amico,
Sabina Zawadzka,
Henry Anyimadu
Publication year - 2020
Publication title -
respiratory medicine case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.42
H-Index - 14
ISSN - 2213-0071
DOI - 10.1016/j.rmcr.2020.101140
Subject(s) - medicine , gold standard (test) , covid-19 , declaration , isolation (microbiology) , coronavirus , social distance , test (biology) , virology , diagnostic test , global health , intensive care medicine , emergency medicine , disease , outbreak , pathology , bioinformatics , infectious disease (medical specialty) , public health , paleontology , political science , law , biology
The first case of the novel Coronavirus Diseases (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was detected in Wuhan, China in December 2019. On January 30, 2020, the World Health Organization declared a global health emergency. Countries around the world advised social distancing, businesses and schools closed, while health care workers faced a viral war. With the declaration of a global emergency, a test to rapidly detect the SARS-CoV-2 was developed to ensure swift isolation of infected persons to prevent spread of disease. Currently, the gold standard for test is Reverse Transcriptase Polymerase Chain Reaction (RT-PCR); however, patients with a high clinical suspicion for COVID-19 can sometimes have multiple negative tests. We discuss a patient under investigation (PUI) who had classic findings of COVID-19 but repeatedly tested negative from nasopharyngeal swabs until a fifth sample obtained from a deep suctioning was tested.
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