Metabolic programming of macrophage functions and pathogens control | Zendy

Sue-jie Koo | Zendy; Nisha Garg | Zendy

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Metabolic programming of macrophage functions and pathogens control

Author(s) -

Sue-jie Koo,

Nisha Garg

Publication year - 2019

Publication title -

redox biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.059

H-Index - 88

ISSN - 2213-2317

DOI - 10.1016/j.redox.2019.101198

Subject(s) - macrophage polarization , bioenergetics , metabolic control analysis , proinflammatory cytokine , metabolic pathway , macrophage , biology , cell function , cell metabolism , energy metabolism , metabolic network , immunology , inflammation , microbiology and biotechnology , metabolism , computational biology , cell , mitochondrion , genetics , biochemistry , endocrinology , insulin , in vitro

Macrophages (Mφ) are central players in mediating proinflammatory and immunomodulatory functions. Unchecked Mφ activities contribute to pathology across many diseases, including those caused by infectious pathogens and metabolic disorders. A fine balance of Mφ responses is crucial, which may be achieved by enforcing appropriate bioenergetics pathways. Metabolism serves as the provider of energy, substrates, and byproducts that support differential Mφ characteristics. The metabolic properties that control the polarization and response of Mφ remain to be fully uncovered for use in managing infectious diseases. Here, we review the various metabolic states in Mφ and how they influence the cell function.

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