Open AccessDistinct TNF-alpha and HLA polymorphisms associate with fibrotic and non-fibrotic subtypes of hypersensitivity pneumonitis
Author(s) -
Cláudia Freitas,
Bruno Lima,
Natália Melo,
Patrícia Caetano Mota,
Hélder Novais Bastos,
Helena Alves,
Oksana Sokhatska,
Luís Delgado,
António Morais
Publication year - 2021
Publication title -
pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.826
H-Index - 22
eISSN - 2531-0437
pISSN - 2531-0429
DOI - 10.1016/j.pulmoe.2021.08.013
Subject(s) - hypersensitivity pneumonitis , medicine , allele , genotype , immunology , fibrosis , asymptomatic , gastroenterology , human leukocyte antigen , lung , pathology , gene , antigen , biology , genetics
Since Hypersensitivity Pneumonitis (HP) categorization in fibrotic and nonfibrotic/inflammatory types seems to be more consistent with the distinctive clinical course and outcomes, recent international guidelines recommended the use of this classification. Moreover, fibrotic subtype may share immunogenetic and pathophysiological mechanisms with other fibrotic lung diseases.
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