Effects of Curcumin and Pentagamavunon-0 Against Dengue-2 Virus Infection in Vero Cells; an in Vitro Study | Zendy

Dewi Marbawati | Zendy; Sitti Rahmah Umniyati | Zendy

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Effects of Curcumin and Pentagamavunon-0 Against Dengue-2 Virus Infection in Vero Cells; an in Vitro Study

Author(s) -

Dewi Marbawati,

Sitti Rahmah Umniyati

Publication year - 2015

Publication title -

procedia environmental sciences

Language(s) - English

Resource type - Journals

ISSN - 1878-0296

DOI - 10.1016/j.proenv.2015.01.033

Subject(s) - curcumin , vero cell , incubation period , incubation , in vitro , dengue virus , dengue fever , virology , biology , virus , microbiology and biotechnology , chemistry , pharmacology , biochemistry

The research aims was to determine the cytotoxic effects and the highest safe concentration of curcumin and PGV-0 on vero cells. This research also compare the effect of curcumin and PGV-0 against vero cells infected by Dengue virus (in vitro) in one and three days incubation period. The highest safe concentrations against vero cells from curcumin was 6.25 ppm and 1.5625 ppm for PGV-0. Immunocytochemistry test of curcumin and PGV-0 in both incubation period (one and three days) shows no significant difference (significant value 0.925), but RT-PCR result indicates that PGV - 0 have potential antiviral better than curcumin.

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