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Bone Marrow–Derived and Adipose‐Derived Mesenchymal Stem Cell Therapy in Primary Knee Osteoarthritis: A Narrative Review
Author(s) -
Jayaram Prathap,
Ikpeama Uzoh,
Rothenberg Joshua B.,
Malanga Gerard A.
Publication year - 2019
Publication title -
pmandr
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.617
H-Index - 66
eISSN - 1934-1563
pISSN - 1934-1482
DOI - 10.1016/j.pmrj.2018.06.019
Subject(s) - medicine , mesenchymal stem cell , narrative review , osteoarthritis , adipose tissue , bone marrow , context (archaeology) , cartilage , regenerative medicine , cell therapy , stem cell , bioinformatics , pathology , intensive care medicine , anatomy , alternative medicine , biology , paleontology , genetics
Regenerative medicine in the context of musculoskeletal injury is a broad term that offers potential therapeutic solutions to restore or repair damaged tissue. The current focus in recent literature and clinical practice has been on cell based therapy. In particular, much attention has been centered on autologous bone marrow concentrate and adipose‐derived mesenchymal stem cells (MSCs) for cartilage and tendon disorders. This article provides an overview of MSC‐derived therapy and offers a comprehensive review of adipose‐ and bone marrow–derived MSC therapy in primary knee osteoarthritis. Level of Evidence IV