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Safety Considerations in the Use of Botulinum Toxins in Children With Cerebral Palsy
Author(s) -
Apkon Susan D.,
Cassidy Danielle
Publication year - 2010
Publication title -
pmandr
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.617
H-Index - 66
eISSN - 1934-1563
pISSN - 1934-1482
DOI - 10.1016/j.pmrj.2010.02.006
Subject(s) - medicine , cerebral palsy , spasticity , botulinum toxin , adverse effect , food and drug administration , intensive care medicine , pediatrics , anesthesia , physical medicine and rehabilitation , pharmacology
The use of botulinum toxins to decrease spasticity in children with cerebral palsy has become standard of care during the past decade. In 2008 reports of severe adverse events, including death, were reported in children who received injections of these medications. The following discussion focuses on the background of these reports, the response of the U.S. Food and Drug Administration, as well as the safety profile and pharmacokinetics of botulinum toxins. Finally, the authors will offer their perspective on the safe use of botulinum toxins.