The α7 nicotinic acetylcholine receptor positive allosteric modulator prevents lipopolysaccharide-induced allodynia, hyperalgesia and TNF-α in the hippocampus in mice | Zendy

Muzaffar Abbas | Zendy; Sami I. Alzarea | Zendy; Roger L. Papke | Zendy; Shafiqur Rahman | Zendy

Open Access

The α7 nicotinic acetylcholine receptor positive allosteric modulator prevents lipopolysaccharide-induced allodynia, hyperalgesia and TNF-α in the hippocampus in mice

Author(s) -

Muzaffar Abbas,

Sami I. Alzarea,

Roger L. Papke,

Shafiqur Rahman

Publication year - 2019

Publication title -

pharmacological reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.706

H-Index - 83

eISSN - 2299-5684

pISSN - 1734-1140

DOI - 10.1016/j.pharep.2019.07.001

Subject(s) - allosteric modulator , allosteric regulation , nicotinic agonist , pharmacology , chemistry , acetylcholine receptor , nicotinic acetylcholine receptor , neuroscience , hippocampus , receptor , medicine , psychology , biochemistry

Previous studies have shown that α7 nicotinic acetylcholine receptor (nAChR) has a critical role in the regulation of pain sensitivity and neuroinflammation. However, pharmacological effects of α7 nAChR activation in the hippocampus on neuroinflammatory mechanisms associated with allodynia and hyperalgesia remain unknown. We have determined the effects of 3a,4,5,9b-tetrahydro-4-(1-naphthalenyl)-3H-cyclopentan[c]quinoline-8-sulfonamide (TQS), an α7 nAChR positive allosteric modulator, on lipopolysaccharide (LPS)-induced allodynia and hyperalgesia in mice. We also evaluated the effects of TQS on immunoreactivity of microglial marker ionized-calcium binding adaptor molecule 1 (Iba-1), phospho-nuclear factor-κB (p-NF-κB p 65 ), tumor necrosis factor-alpha (TNF-α), and norepinephrine (NE) level.

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