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Expression and activation of peroxisome proliferator‐activated receptors in growth plate chondrocytes
Author(s) -
Shao Yvonne Y.,
Wang Lai,
Hicks David G.,
Tarr Shan,
Ballock R. Tracy
Publication year - 2005
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1016/j.orthres.2005.02.011
Subject(s) - microbiology and biotechnology , ciglitazone , peroxisome proliferator activated receptor , receptor , nuclear receptor , apoptosis , chondrocyte , cell growth , chemistry , peroxisome proliferator activated receptor delta , biology , cartilage , transcription factor , biochemistry , anatomy , gene
Peroxisome proliferator‐activated receptor γ (PPAR‐γ) is a nuclear hormone receptor that is involved in a wide range of cellular processes. Although it is known that PPAR‐γ plays an important role in cell cycle control, inflammation, apoptotic cell death, and other cellular processes, the role of PPAR‐γ in the normal and pathological function of growth plate chondrocytes has not been investigated. The purpose of this study was to determine if PPARs are expressed in growth plate chondrocytes and to describe the biological effect of PPAR activation in these cells. The results demonstrate the presence of three PPAR isoforms (α, δ, and γ) in growth plate cartilage. Activation of PPAR‐γ by ciglitazone in growth plate chondrocytes inhibits T 3 induced terminal differentiation and promotes apoptosis through increased levels of caspase 3/7 activity and decreased expression of the anti‐apoptotic protein Bcl‐2. © 2005 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved.