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Mechanical interface conditions affect morphology and cellular activity of sclerotic bone rims forming around experimental loaded implants
Author(s) -
Vestermark Marianne Toft,
Bechtold Joan E.,
Swider Pascal,
Søballe Kjeld
Publication year - 2004
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1016/j.orthres.2003.10.012
Subject(s) - implant , resorption , materials science , fixation (population genetics) , perforation , biomedical engineering , chemistry , anatomy , composite material , medicine , pathology , surgery , biochemistry , punching , gene
A characteristic bony structure found at revision surgery for failed joint replacement, and implicated as being associated with poorer subsequent implant fixation, is a sclerotic bone rim (SB rim). This study is a histomorphometric analysis of the SB rim formed around an experimental canine micro‐motion implant system under stable or unstable conditions with polyethylene (PE) particles, after 8 weeks. A point count histomorphometric analysis was performed to determine the cellular activity at the surface of the SB rim, and the morphology of the structure was determined by image analysis. A SB rim was found to form under both stable and unstable conditions, but with unstable conditions the rim was more distinct, thick, continuous, and was located near the drill hole, and had high and ongoing formative activity at both surfaces with little resorption. Under stable conditions, thinner second or third SB rims were observed. The difference in width and distance between implant and the SB rim is significant ( p < 0.05), as was the difference in fraction of resorption surfaces at the SB surface facing the implant. This study observed an in vivo primary bone response to controlled stable and unstable loaded implants. Sclerosis of trabeculae in a semi‐continuous SB rim can serve to isolate the implant from the marrow space. The increases in SB rim width and continuity is consistent with the previously demonstrated knowledge that increase of total bone mass and low risk for trabeculae perforation is the consequence of low resorptive and high formative activity. © 2003 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved.