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The effectiveness of polyethylene versus titanium particles in inducing osteolysis in vivo
Author(s) -
von Knoch Marius,
Jewison Donna E.,
Sibonga Jean D.,
Sprecher Christoph,
Morrey Bernard F.,
Loer Franz,
Berry Daniel J.,
Scully Sean P.
Publication year - 2004
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1016/j.orthres.2003.08.013
Subject(s) - osteolysis , polyethylene , bone resorption , titanium , materials science , resorption , osteoclast , medicine , dentistry , composite material , metallurgy , pathology , receptor
Bearing surface wear and periprosthetic osteolysis due to wear particles are among the most common reasons for joint replacement failure. A murine calvarial model of wear particle‐induced osteolysis has been used to identify different biologic factors associated with this problem and to test nonsurgical methods of modulating the host response to particulate debris. This model has utilized titanium particles, however, in clinical practice the most common source of particulate debris is polyethylene particles from bearing surface wear. We now report a calvarial model of wear particle‐induced osteolysis based on commercially available polyethylene particles. We found that compared to sham surgery osteoclast recruitment and bone resorption can be induced by introduction of the titanium particles or polyethylene particles. However, bone resorption was significantly higher with polyethylene particles compared to titanium particles ( p = 0.02). We consider the polyethylene based murine calvarial model of wear particle‐induced osteolysis a reliable and clinically relevant tool to understand the host factors and potential pharmacologic interventions that can influence wear debris generated osteolysis. This model might serve as an extension of the well‐established titanium based bone resorption model. © 2003 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved.