Open AccessBrain anatomical covariation patterns linked to binge drinking and age at first full drink
Author(s) -
Yihong Zhao,
R. Todd Constable,
Denise A. Hien,
Tammy Chung,
Marc N. Potenza
Publication year - 2021
Publication title -
neuroimage. clinical
Language(s) - English
Resource type - Journals
ISSN - 2213-1582
DOI - 10.1016/j.nicl.2020.102529
Subject(s) - generalizability theory , binge drinking , grey matter , psychology , brainstem , human connectome project , variance components , medicine , audiology , neuroscience , functional connectivity , developmental psychology , statistics , poison control , white matter , environmental health , mathematics , suicide prevention , magnetic resonance imaging , radiology
Highlights • We identified a reproducible cortical and subcortical brain structural covariation pattern.• A novel pattern discovery method Joint and Individual Variance Explained (JIVE) was used.• The cortical and subcortical structural covariation pattern is related to alcohol use initiation.• The identified pattern is dominated by covariation among brainstem, thalamus and PFC.• A thalamic-PFC-brainstem circuitry might be related to alcohol use initiation.