Open AccessRevealing vascular abnormalities and measuring small vessel density in multiple sclerosis lesions using USPIO
Author(s) -
Sagar Buch,
Subramanian Karthikeyan,
Pavan Jella,
Yongsheng Chen,
Zhen Wu,
Kamran Shah,
Evanthia Bernitsas,
Yulin Ge,
E. Mark Haacke
Publication year - 2020
Publication title -
neuroimage clinical
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.772
H-Index - 68
ISSN - 2213-1582
DOI - 10.1016/j.nicl.2020.102525
Subject(s) - multiple sclerosis , medicine , susceptibility weighted imaging , pathology , neuroscience , magnetic resonance imaging , psychology , radiology , psychiatry
Highlights • Ferumoxytol, a USPIO agent, was used to reveal microvasculature in six RRMS patients.• Lesion pertaining vascular abnormalities were identified using SWI-FLAIR data.• Detection of vascular signs increased from 54% to 93% in the presence of USPIO.• Lesional vessel density was higher than the perilesional vessel density in all patients.
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