Functional connectivity between resting-state networks reflects decline in executive function in Parkinson’s disease: A longitudinal fMRI study | Zendy

Lennard I. Boon | Zendy; Dagmar H. Hepp | Zendy; Linda Douw | Zendy; Noëlle van Geenen | Zendy; Tommy A.A. Broeders | Zendy; Jeroen J.G. Geurts | Zendy; Henk W. Berendse | Zendy; Menno M. Schoonheim | Zendy

Open Access

Functional connectivity between resting-state networks reflects decline in executive function in Parkinson’s disease: A longitudinal fMRI study

Author(s) -

Lennard I. Boon,

Dagmar H. Hepp,

Linda Douw,

Noëlle van Geenen,

Tommy A.A. Broeders,

Jeroen J.G. Geurts,

Henk W. Berendse,

Menno M. Schoonheim

Publication year - 2020

Publication title -

neuroimage clinical

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.772

H-Index - 68

ISSN - 2213-1582

DOI - 10.1016/j.nicl.2020.102468

Subject(s) - resting state fmri , parkinson's disease , neuroscience , functional connectivity , disease , psychology , cognitive psychology , medicine

Highlights • Over time, Parkinson’s disease (PD) patients declined on multiple cognitive domains.• Executive dysfunction was related to interactions between specific resting-state networks.• These interactions involved deep grey matter, frontoparietal, and attentional networks.• Destabilization of functional network interactions may influence PD progression.

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