Stable inhibition-related inferior frontal hypoactivation and fronto-limbic hyperconnectivity in obsessive–compulsive disorder after concentrated exposure therapy | Zendy

Anders Lillevik Thorsen | Zendy; Stella J. de Wit | Zendy; Pernille Hagland | Zendy; Olga Therese Ousdal | Zendy; Bjarne Hansen | Zendy; Kristen Hagen | Zendy; Gerd Kvale | Zendy; Odile A. van den Heuvel | Zendy

Open Access

Stable inhibition-related inferior frontal hypoactivation and fronto-limbic hyperconnectivity in obsessive–compulsive disorder after concentrated exposure therapy

Author(s) -

Anders Lillevik Thorsen,

Stella J. de Wit,

Pernille Hagland,

Olga Therese Ousdal,

Bjarne Hansen,

Kristen Hagen,

Gerd Kvale,

Odile A. van den Heuvel

Publication year - 2020

Publication title -

neuroimage clinical

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.772

H-Index - 68

ISSN - 2213-1582

DOI - 10.1016/j.nicl.2020.102460

Subject(s) - amygdala , functional magnetic resonance imaging , stop signal , neuroscience , psychology , medial frontal gyrus , frontal lobe , inferior frontal gyrus , middle frontal gyrus , audiology , medicine , electrical engineering , engineering , latency (audio)

Highlights• Less IFG activation and more fronto-limbic connectivity was found in OCD. • IFG hypoactivation and fronto-limbic hyperconnectivity persisted after exposure therapy. • Activation and connectivity before treatment did not predict treatment outcome.

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