The bed nucleus of the stria terminalis and functionally linked neurocircuitry modulate emotion processing and HPA axis dysfunction in posttraumatic stress disorder | Zendy

Samir Awasthi | Zendy; Hong Pan | Zendy; Joseph E. LeDoux | Zendy; Marylène Cloître | Zendy; Margaret Altemus | Zendy; Bruce S. McEwen | Zendy; David Silbersweig | Zendy; Emily Stern | Zendy

Open Access

The bed nucleus of the stria terminalis and functionally linked neurocircuitry modulate emotion processing and HPA axis dysfunction in posttraumatic stress disorder

Author(s) -

Samir Awasthi,

Hong Pan,

Joseph E. LeDoux,

Marylène Cloître,

Margaret Altemus,

Bruce S. McEwen,

David Silbersweig,

Emily Stern

Publication year - 2020

Publication title -

neuroimage clinical

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.772

H-Index - 68

ISSN - 2213-1582

DOI - 10.1016/j.nicl.2020.102442

Subject(s) - stria terminalis , psychology , anterior cingulate cortex , amygdala , neuroscience , dorsolateral prefrontal cortex , prefrontal cortex , functional magnetic resonance imaging , medicine , cognition

Highlights • Task-based functional cooccurrence (tbFC) elucidates role of BNST in human PTSD neurocircuitry.• The BNST is hyperactive during the processing of trauma-related words in PTSD.• BNST activity correlates to PTSD symptom severity and reduced diurnal cortisol index.• The BNST has positive tbFC with negative emotion- and stress-related neurocircuitry.• The BNST has negative tbFC with executive function and stress regulation neurocircuitry.

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